QI Project to determine the incidence of hyperoxia on a mixed general intensive care unit, monitoring and improvement using an automated strategy. Completed QI project, superceeded by research role as principle investigator for the UKROX trial locally.
Laboratory based project to investigate the role of nociceptin in sepsis, comparing its release in healthy volunteers and critically ill patients with sepsis. Completed PhD project, leading to a number of publications and experience in confocal microscopy, bioassay development and image processing
Training programme director for Acute Care Common Stem, Anaesthetics stream. An innovative role bridging the schools of anaesthesia and emergency medicine, focusing on educator and postgraduate doctor support with implementation of the new curriculum, quality and assessment.
Published in Journal of Pharmacology and Experimental Therapeutics, 2004
Recommended citation: Carra G, Rizzi A, Guerrini R, Barnes TA, McDonald J, Hebbes CP, Mela F, Kenigs VA, Marzola G, Rizzi D, Gavioli E. [(pF) Phe4, Arg14, Lys15] N/OFQ-NH2 (UFP-102), a highly potent and selective agonist of the nociceptin/orphanin FQ receptor. Journal of Pharmacology and Experimental Therapeutics. 2005;312:1114-23 http://dx.doi.org/10.1124/jpet.104.077339
Published in Bioorganic & medicinal chemistry, 2005
Recommended citation: Trapella C, Guerrini R, Piccagli L, Spagnolo B, Rubini S, Fanton G, Hebbes CP, et al. Identification of an achiral analogue of J-113397 as potent nociceptin/orphanin FQ receptor antagonist. Bioorganic & medicinal chemistry. 2006 ;14:692-704 http://dx.doi.org/10.1016/j.bmc.2005.08.049
Published in Journal of Pharmacology and Experimental Therapeutics, 2006
Recommended citation: Spagnolo B, Carra G, Fantin M, Fischetti C, Hebbes CP, McDonald J, et al. Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [()-cis-1-methyl-7-[[4-(2, 6-dichlorophenyl) piperidin-1-yl] methyl]-6, 7, 8, 9-tetrahydro-5H-benzocyclohepten-5-ol]: in vitro studies. Journal of Pharmacology and Experimental Therapeutics. 2007;321:961-7 http://dx.doi.org/10.1124/jpet.106.116764
Published in Peptides, 2006
Recommended citation: Vergura R, Valenti E, Hebbes CP, Gavioli EC, Spagnolo B, McDonald J, et al. Dmt-Tic-NH-CH2-Bid (UFP-502), a potent DOP receptor agonist: in vitro and in vivo studies. Peptides. 2006;27:3322-30 http://dx.doi.org/10.1016/j.peptides.2006.07.015
Published in Anaesthesia & Intensive Care Medicine, 2008
Recommended citation: Hebbes CP, Lambert D. Non-opioid analgesic drugs. Anaesthesia & Intensive Care Medicine. 2008;9:79-83 http://dx.doi.org/10.1016/j.mpaic.2007.11.012
Published in Pancreas, 2008
Recommended citation: Garcea G, Gouda M, Hebbes CP, Ong SL, Neal CP, Dennison AR, et al. Predictors of severity and survival in acute pancreatitis: validation of the efficacy of early warning scores. Pancreas. 2008;37:54-61 http://dx.doi.org/10.1097/MPA.0b013e3181771451
Published in Anaesthesia & Intensive Care Medicine, 2011
Recommended citation: Hebbes CP, Lambert D. Non-opioid analgesics. Anaesthesia & Intensive Care Medicine. 2011;12:69-72 http://dx.doi.org//10.1016/j.mpaic.2010.10.022
Published in PloS one, 2013
Recommended citation: Brookes ZL, Stedman EN, Brown NJ, Hebbes CP, Guerrini R, Calo G, et al. The nociceptin/orphanin FQ receptor antagonist UFP-101 reduces microvascular inflammation to lipopolysaccharide in vivo. PloS one. 2013;8:e74943 http://dx.doi.org/10.1371/journal.pone.0074943
Published in Anaesthesia & Intensive Care Medicine, 2013
Recommended citation: Hebbes CP, Lambert D. Non-opioid analgesics. Anaesthesia & Intensive Care Medicine. 2013;14:510-3 http://dx.doi.org/10.1016/j.mpaic.2013.08.011
Published in Anaesthesia & Intensive Care Medicine, 2015
Recommended citation: Hebbes CP, Thompson JP. Drugs acting on the heart: anti-arrhythmics. Anaesthesia & Intensive Care Medicine. 2015;16:232-6 http://dx.doi.org/10.1016/j.mpaic.2015.02.009
Published in Anaesthesia & Intensive Care Medicine, 2016
Recommended citation: Hebbes CP. Pharmacological modulation of cardiac function and blood vessel calibre. Anaesthesia & Intensive Care Medicine. 2016;17:48-54 http://dx.doi.org/10.1016/j.mpaic.2015.10.009
Published in Anaesthesia & Intensive Care Medicine, 2016
Recommended citation: Hebbes CP. Non-opioid analgesics. Anaesthesia & Intensive Care Medicine. 2016;17:469-72 http://dx.doi.org/10.1016/j.mpaic.2016.06.013
Published in Anaesthesia & Intensive Care Medicine., 2018
Recommended citation: Hebbes CP, Thompson JP. Drugs acting on the heart: anti-arrhythmics. Anaesthesia & Intensive Care Medicine. 2018;19:370-4 http://dx.doi.org/10.1016/j.mpaic.2018.04.009
Published in Bouch C, Cousins J. Core Topics in Anaesthesia and Perioperative Care of the Morbidly Obese Surgical Patient, 2018
Recommended citation: Hebbes CP, Thompson JP. Chapter 9: Drug Compartments and Body Systems In: Bouch C, Cousins J. Core Topics in Anaesthesia and Perioperative Care of the Morbidly Obese Surgical Patient. Cambridge University Press, 2018 http://dx.doi.org/10.1017/9781316681053.010
Published in BJA Education, 2018
Recommended citation: Hebbes CP, Thompson JP. Pharmacokinetics of anaesthetic drugs at extremes of weight. BJA Education. 2018; 18: 364-70 http://dx.doi.org/10.1016/j.bjae.2018.09.001
Published in Anaesthesia & Intensive Care Medicine, 2018
Recommended citation: Hebbes CP. Pharmacological modulation of cardiac function and blood vessel calibre. Anaesthesia & Intensive Care Medicine. 2018;12:648-55 http://dx.doi.org/10.1016/j.mpaic.2018.09.003
Published in Thompson JP, Moppett I. Smith & Aitkenheads Textbook of Anaesthesia. Elsevier, 2019, 2019
Hebbes CP, Lambert, DG. Chapter 1: General principles of pharmacology. In: Thompson JP, Moppett I. Smith & Aitkenheads Textbook of Anaesthesia. Elsevier, 2019
Recommended citation: Hebbes CP, Lambert, DG. Chapter 1: General principles of pharmacology. In: Thompson JP, Moppett I. Smith & Aitkenheads Textbook of Anaesthesia. Elsevier, 2019 http://books.google.com/books?id=MJuRDwAAQBAJ
Published in PLOS One, 2022
Recommended citation: Bird MF, Hebbes CP, Scott SWM, Wilets J, Thompson JP, Lambert DG. A Novel Bioassay to Detect Nociceptin/Orphanin FQ Release from Single Human Polymorphonuclear Cells. PLOS One. 2022 PLOS ONE 17(5): e0268868
Recommended citation: Bird MF, Hebbes CP, Scott SWM, Wilets J, Thompson JP, Lambert DG. A Novel Bioassay to Detect Nociceptin/Orphanin FQ Release from Single Human Polymorphonuclear Cells. PLOS One. 2022 PLOS ONE 17(5): e0268868 https://doi.org/10.1371/journal.pone.0268868
Published in British Journal of Pharmacology, 2023
Recommended citation: Bird MF, Hebbes CP, Tamang J, Wilets J, Thompson JP, Calo G, Lambert DG. In vitro sepsis upregulates Nociceptin/Orphanin FQ receptor expression and function on human T- but not B-cells. Br J Pharmcol. 2023 (in press)
Recommended citation: Bird MF, Hebbes CP, Tamang J, Wilets J, Thompson JP, Calo G, Lambert DG. In vitro sepsis upregulates Nociceptin/Orphanin FQ receptor expression and function on human T- but not B-cells. Br J Pharmacol 2023 (in press) https://doi.org/10.1111/bph.16088
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This was a poster presented at the RCoA college tutors day on our experiences of using Office 365
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This was a talk given as part of the regional research education day, to a trainee and consultant audience about life as a trainee anaesthetist with a research background
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This poster presentation of a baseline audit covered the incidence of hyperoxia, and issues of prescribing and monitoring Oxygen delivery on the intensive care unit
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This talk as part of the RCoA updates series covered issues in pharmacokinetics at extremes of weight, including approaches to TCI, TIVA, and recent guidelines for drug dosing.
Undergraduate course, University 1, Department, 2014
This is a description of a teaching experience. You can use markdown like any other post.
Workshop, University 1, Department, 2015
This is a description of a teaching experience. You can use markdown like any other post.