Publications

In vitro sepsis upregulates Nociceptin/Orphanin FQ receptor expression and function on human T- but not B-cells.

Published in British Journal of Pharmacology, 2023

Recommended citation: Bird MF, Hebbes CP, Tamang J, Wilets J, Thompson JP, Calo G, Lambert DG. In vitro sepsis upregulates Nociceptin/Orphanin FQ receptor expression and function on human T- but not B-cells. Br J Pharmcol. 2023 (in press)

Recommended citation: Bird MF, Hebbes CP, Tamang J, Wilets J, Thompson JP, Calo G, Lambert DG. In vitro sepsis upregulates Nociceptin/Orphanin FQ receptor expression and function on human T- but not B-cells. Br J Pharmacol 2023 (in press) https://doi.org/10.1111/bph.16088

A Novel Bioassay to Detect Nociceptin/Orphanin FQ Release from Single Human Polymorphonuclear Cells.

Published in PLOS One, 2022

Recommended citation: Bird MF, Hebbes CP, Scott SWM, Wilets J, Thompson JP, Lambert DG. A Novel Bioassay to Detect Nociceptin/Orphanin FQ Release from Single Human Polymorphonuclear Cells. PLOS One. 2022 PLOS ONE 17(5): e0268868

Recommended citation: Bird MF, Hebbes CP, Scott SWM, Wilets J, Thompson JP, Lambert DG. A Novel Bioassay to Detect Nociceptin/Orphanin FQ Release from Single Human Polymorphonuclear Cells. PLOS One. 2022 PLOS ONE 17(5): e0268868 https://doi.org/10.1371/journal.pone.0268868

General principles of pharmacology

Published in Thompson JP, Moppett I. Smith & Aitkenheads Textbook of Anaesthesia. Elsevier, 2019, 2019

Hebbes CP, Lambert, DG. Chapter 1: General principles of pharmacology. In: Thompson JP, Moppett I. Smith & Aitkenheads Textbook of Anaesthesia. Elsevier, 2019

Recommended citation: Hebbes CP, Lambert, DG. Chapter 1: General principles of pharmacology. In: Thompson JP, Moppett I. Smith & Aitkenheads Textbook of Anaesthesia. Elsevier, 2019 http://books.google.com/books?id=MJuRDwAAQBAJ

Pharmacological modulation of cardiac function and blood vessel calibre

Published in Anaesthesia & Intensive Care Medicine, 2018

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Recommended citation: Hebbes CP. Pharmacological modulation of cardiac function and blood vessel calibre. Anaesthesia & Intensive Care Medicine. 2018;12:648-55 http://dx.doi.org/10.1016/j.mpaic.2018.09.003

Pharmacokinetics of anaesthetic drugs at extremes of weight

Published in BJA Education, 2018

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Recommended citation: Hebbes CP, Thompson JP. Pharmacokinetics of anaesthetic drugs at extremes of weight. BJA Education. 2018; 18: 364-70 http://dx.doi.org/10.1016/j.bjae.2018.09.001

Chapter 9: Drug Compartments and Body Systems

Published in Bouch C, Cousins J. Core Topics in Anaesthesia and Perioperative Care of the Morbidly Obese Surgical Patient, 2018

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Recommended citation: Hebbes CP, Thompson JP. Chapter 9: Drug Compartments and Body Systems In: Bouch C, Cousins J. Core Topics in Anaesthesia and Perioperative Care of the Morbidly Obese Surgical Patient. Cambridge University Press, 2018 http://dx.doi.org/10.1017/9781316681053.010

Drugs acting on the heart: anti-arrhythmics.

Published in Anaesthesia & Intensive Care Medicine., 2018

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Recommended citation: Hebbes CP, Thompson JP. Drugs acting on the heart: anti-arrhythmics. Anaesthesia & Intensive Care Medicine. 2018;19:370-4 http://dx.doi.org/10.1016/j.mpaic.2018.04.009

Non-opioid analgesics

Published in Anaesthesia & Intensive Care Medicine, 2016

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Recommended citation: Hebbes CP. Non-opioid analgesics. Anaesthesia & Intensive Care Medicine. 2016;17:469-72 http://dx.doi.org/10.1016/j.mpaic.2016.06.013

Pharmacological modulation of cardiac function and blood vessel calibre

Published in Anaesthesia & Intensive Care Medicine, 2016

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Recommended citation: Hebbes CP. Pharmacological modulation of cardiac function and blood vessel calibre. Anaesthesia & Intensive Care Medicine. 2016;17:48-54 http://dx.doi.org/10.1016/j.mpaic.2015.10.009

Drugs acting on the heart: anti-arrhythmics

Published in Anaesthesia & Intensive Care Medicine, 2015

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Recommended citation: Hebbes CP, Thompson JP. Drugs acting on the heart: anti-arrhythmics. Anaesthesia & Intensive Care Medicine. 2015;16:232-6 http://dx.doi.org/10.1016/j.mpaic.2015.02.009

Non-opioid analgesics

Published in Anaesthesia & Intensive Care Medicine, 2013

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Recommended citation: Hebbes CP, Lambert D. Non-opioid analgesics. Anaesthesia & Intensive Care Medicine. 2013;14:510-3 http://dx.doi.org/10.1016/j.mpaic.2013.08.011

The nociceptin/orphanin FQ receptor antagonist UFP-101 reduces microvascular inflammation to lipopolysaccharide in vivo

Published in PloS one, 2013

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Recommended citation: Brookes ZL, Stedman EN, Brown NJ, Hebbes CP, Guerrini R, Calo G, et al. The nociceptin/orphanin FQ receptor antagonist UFP-101 reduces microvascular inflammation to lipopolysaccharide in vivo. PloS one. 2013;8:e74943 http://dx.doi.org/10.1371/journal.pone.0074943

Non-opioid analgesics

Published in Anaesthesia & Intensive Care Medicine, 2011

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Recommended citation: Hebbes CP, Lambert D. Non-opioid analgesics. Anaesthesia & Intensive Care Medicine. 2011;12:69-72 http://dx.doi.org//10.1016/j.mpaic.2010.10.022

Predictors of severity and survival in acute pancreatitis: validation of the efficacy of early warning scores

Published in Pancreas, 2008

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Recommended citation: Garcea G, Gouda M, Hebbes CP, Ong SL, Neal CP, Dennison AR, et al. Predictors of severity and survival in acute pancreatitis: validation of the efficacy of early warning scores. Pancreas. 2008;37:54-61 http://dx.doi.org/10.1097/MPA.0b013e3181771451

Non-opioid analgesic drugs

Published in Anaesthesia & Intensive Care Medicine, 2008

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Recommended citation: Hebbes CP, Lambert D. Non-opioid analgesic drugs. Anaesthesia & Intensive Care Medicine. 2008;9:79-83 http://dx.doi.org/10.1016/j.mpaic.2007.11.012

Dmt-Tic-NH-CH2-Bid (UFP-502), a potent DOP receptor agonist: in vitro and in vivo studies

Published in Peptides, 2006

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Recommended citation: Vergura R, Valenti E, Hebbes CP, Gavioli EC, Spagnolo B, McDonald J, et al. Dmt-Tic-NH-CH2-Bid (UFP-502), a potent DOP receptor agonist: in vitro and in vivo studies. Peptides. 2006;27:3322-30 http://dx.doi.org/10.1016/j.peptides.2006.07.015

Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [())-cis-1-methyl-7-[[4-(2, 6-dichlorophenyl) piperidin-1-yl] methyl]-6, 7, 8, 9-tetrahydro-5H-benzocyclohepten-5-ol]: in vitro studies

Published in Journal of Pharmacology and Experimental Therapeutics, 2006

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Recommended citation: Spagnolo B, Carra G, Fantin M, Fischetti C, Hebbes CP, McDonald J, et al. Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [()-cis-1-methyl-7-[[4-(2, 6-dichlorophenyl) piperidin-1-yl] methyl]-6, 7, 8, 9-tetrahydro-5H-benzocyclohepten-5-ol]: in vitro studies. Journal of Pharmacology and Experimental Therapeutics. 2007;321:961-7 http://dx.doi.org/10.1124/jpet.106.116764

Identification of an achiral analogue of J-113397 as potent nociceptin/orphanin FQ receptor antagonist

Published in Bioorganic & medicinal chemistry, 2005

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Recommended citation: Trapella C, Guerrini R, Piccagli L, Spagnolo B, Rubini S, Fanton G, Hebbes CP, et al. Identification of an achiral analogue of J-113397 as potent nociceptin/orphanin FQ receptor antagonist. Bioorganic & medicinal chemistry. 2006 ;14:692-704 http://dx.doi.org/10.1016/j.bmc.2005.08.049

Journal of Pharmacology and Experimental Therapeutics

Published in Journal of Pharmacology and Experimental Therapeutics, 2004

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Recommended citation: Carra G, Rizzi A, Guerrini R, Barnes TA, McDonald J, Hebbes CP, Mela F, Kenigs VA, Marzola G, Rizzi D, Gavioli E. [(pF) Phe4, Arg14, Lys15] N/OFQ-NH2 (UFP-102), a highly potent and selective agonist of the nociceptin/orphanin FQ receptor. Journal of Pharmacology and Experimental Therapeutics. 2005;312:1114-23 http://dx.doi.org/10.1124/jpet.104.077339